CUENCA, Patricia and RAMIREZ, Vanessa. Aberraciones cromosómicas en trabajadoras expuestas a plaguicidas. Rev. biol. trop [online]. , vol, n.3, pp. ABERRACIONES. CROMOSÓMICAS. Dra. Laura Santana Díaz Médico Genetista. Morfología y estructura de los cromosomas humanos. Cariotipo Constitución. PDF | On Jan 1, , Fernado N. Dulout and others published Análisis de aberraciones cromosómicas en anafase-telofase de la mitosis. I. Acción clastogénica.

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Influence of smoking habit on the frequency of micronuclei in human lymphocytes by the cytokinesis block method. Cell division, chromosomal damage and micronucleus formation in peripheral lymphocytes of healthy donors: Chromosomal instability in amniocytes from fetuses of mothers who smoke. Effect of laboratory protocol, scoring criteria, and host factors on the frequency of micronuclei. Chem Res Toxicol ; Kirsch-Volders M, Fenech M. The cytogenetic assay as a measure of genetic instability induced by genotoxic agents.

Conferencia: Impacto de las Aberraciones Cromosómicas en la Salud. ~ Ciber-Genética

The micronuclei assay is considered a practical, universally validated and technically feasible protocol which is useful to evaluate the genetic instability induced by genotoxic agents.

Effect of smoking habit on the frequency of micronuclei in human lymphocytes: Mutability of p53 hotspot codons to benzo a pyrene diol epoxide BPDE and the frequency of p53 mutations in nontumorous human lung. Contributions to the development of a protocol suitable for regulatory submissions from an examination of 16 chemicals with different mechanisms of action and different levels of activity.

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Micronucleus formation in peripheral-blood lymphocytes from smokers and the influence of alcohol- and tea-drinking habits.

Contribution of sex, age, and lifestyle. The cytogenetic assay for the detection of micronuclei CBMN: Micronuclei and chromatid buds are the result of related genotoxic events. Cancer Res ; The in vitro micronucleus technique.

Sister chromatid exchange and micronucleus frequency in human lymphocytes of 1, subjects in an Italian population: Al contrario, varias publicaciones han detectado diferencias entre grupos de fumadores y no fumadores: Micronucleus monitoring of a floriculturist population from western Liguria, Italy. Zalacain 1L. High susceptibility to lung cancer analyzed in terms of combined genotypes of PIA1 and Mu-class glutathione S-transferase genes.

The cytokinesis-block micronucleus technique: Importance of detecting numerical versus structural chromosome aberrations.

El recuento de MN se debe realizar sobre 1. Clastogenic effect for cigarette smoking but not areca quid chewing as measured by micronuclei in exfoliated buccal mucosal cells. Micronuclei in cytokinesis-blocked lymphocytes as an index of occupational exposure to alkylating cytostatic drugs. Environ Toxicol Chem ; Micronucleus induction in gill cells of green-lipped mussels Perna viridis exposed to mixtures of polycyclic aromatic hydrocarbons and chlorinated pesticides.

The position of the in vitro micronucleus test within the battery of screening for genotoxic potential determination and the regulatory guidelines. What do human micronuclei contain? There are several factors able to modify the number of micronuclei present in a given cell, among them are age, xberraciones, vitamins, medical treatments, daily exposure to genotoxic agents, etc.

The micronucleus assay in human lymphocytes: A protocol for the in vitro micronucleus test. Inhibition of oxidative DNA damage, 8-OHdG, and carbonyl contents in smokers treated with antioxidants vitamin E, vitamin C, beta-carotene cgomosomicas red ginseng. Jpn J Cancer Res ; Norppa H, Falck GC.


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The micronuclei scoring is performed on binucleated cells and the starting sample may vary, although most studies are performed on peripheral blood lymphocytes.

Micronuclei frequencies in hospital workers occupationally exposed to low levels of ionizing radiation: Fenech M, Morley AA. Measurement of micronuclei in lymphocytes. The production of micronuclei from chromosome aberrations in irradiated cultures of human aberracionss.

Evaluation of micronuclei frequency in the cultured peripheral blood lymphocytes of cancer patients before and after radiation treatment. Formation of diastereomeric benzo[a]pyrene diol epoxide-guanine adducts in cromosomixas gene-derived DNA sequences. Micronuclei, nucleoplasmic bridges and nuclear buds induced in folic acid deficient human lymphocytes-evidence for breakage-fusion-bridge cycles in the cytokinesis-block micronucleus assay.

Sex chromosome loss, micronuclei, sister chromatid exchange and aging: Micronuclei in lymphocytes of young patients under antileukemic therapy.

Hainaut P, Pfeifer GP.

Ginseng reduces the micronuclei yield in lymphocytes after irradiation. Factors contributing to chromosome damage in lymphocytes of cigarette smokers.