Fulltext – Transdermal Drug Delivery System of Aceclofenac for Rheumatoid Arthritis An ideal transdermal patch should have flexibility, elasticity and softness. Formulation and biopharmaceutical evaluation of a transdermal patch containing aceclofenac. Rhee YS(1), Nguyen T, Park ES, Chi SC. transdermal matrix type patches to sustain its release characteristics. Key Words: Aceclofenac, Transdermal drug delivery, HPMC, Ethyl.

Author: Mikalabar Zukus
Country: Somalia
Language: English (Spanish)
Genre: Politics
Published (Last): 8 April 2006
Pages: 192
PDF File Size: 7.66 Mb
ePub File Size: 4.93 Mb
ISBN: 471-1-97503-708-1
Downloads: 55523
Price: Free* [*Free Regsitration Required]
Uploader: Ketaur

The transdermal films prolonged the drug release up to 24 h thereby minimizing the dosage frequency unlike the conventional oral drug delivery. The percentage flatness was calculated as:.

Development of matrix type transdermal patches of lercanidipine hydrochloride: International Journal of Pharmacology Volume 11 5: The drug was found to be uniformly dispersed in the transdermal films.

The control group group I received the nonmedicated blank patches.

RJPDFT – Formulation and Evaluation of Transdermal Patch of Aceclofenac

As indicated by Patcjes, the drug was not only dispersed in the matrix but also was available in the surface as appendages which might be responsible for the initial good release followed by the slow and prolonged release of the drug. Primary skin irritancy studies: Out of these various methods of transdermal enhancement of drug permeation, the use of chemical enhancers has been reported to be the best method of increasing transport across the skin. Screening of anti-arthritic, anti-inflammatory and analgesic activity of a polyherbal formulation.


Effects and mechanisms of total glucosides of paeony on adjuvant arthritis in rats. Pregabalin was obtained as gift sample different hydrophilic and hydrophobic polymers acecllfenac, 7. Patch was kept in a desiccator at Weight Variation: On other back side of the rat, provides controlled release which ultimately reduces control patch without drug was placed in a similar the frequency of administration of drug in patients manner.


The formulations with permeation enhancers showed higher percentage of moisture content.

The ratio of the polymers was kept constant. From the table 1, dish containing solution for appropriate time period it was concluded that most appropriate combination of generally at room temperature.

Formulation and biopharmaceutical evaluation of a transdermal patch containing aceclofenac.

The application sites were observed for any erythema and edema on skin surface for 7 days after application and the scoring was done Draize et al. Longitudinal strips were tramsdermal from each film from three different location of the each film. The polymer solution thus obtained was ratio. PIN India S. It was found to be Appropriate size of sin was U.

Formulation and biopharmaceutical evaluation of a transdermal patch containing aceclofenac.

Result of all evaluation carried out in order to detect irritation and parameters was found to be satisfactory within sensitization under conditions of maximal stress which permissible limits. Solution was then filtered and drug specific time interval and equal amount of phosphate content was estimated spectrophotometrically at buffer was replaced each time to maintain volume of nm after suitable dilution. The scanning electron microscopy showed that the drug particles were dispersed in the matrix of the film and was found to be projected on the surface of film also.


Composition and flexibility of thus obtained was then evaluated for various placebo patch of HPMC and PVP combined in different parameters like patdhes parameters, drug ratio is shown below in table 2. Cha d ashekha N.

It also finds its use in Transdermal drug delivery has certain advantages over peripheral diabetic neuropathy, fibromyalgia and acedlofenac other systems of drug administration which in turn therapeutic neuralgia. Development and in-vitro evaluation of diltiazem hydrochloride transdermal patches based on povidone-ethyl cellulose matrices. The rats were allowed free access to drinking water and standard diet.

Matrix type transdermal films loaded with aceclofenac were prepared using solvent evaporation technique Table 1. Enter the email address you signed up with and we’ll email you a reset link. The method is simple to adopt and cost effective.

Related Items Author’s work. Help Center Find new yransdermal papers in: Gupta R, Mukherjee B. The percentage nonuniformity or percentage constriction was calculated as:. For the patients of rheumatoid arthritis, delivering the drugs in transdermal films may not only increase the patient compliance but also provide the immediate and prolonged release of the drug.

This was found to be in good agreement with previous studies Mamatha et al. Arora P, Mukherjee P.