Instruction for self-administration is mentioned in the Package Leaflet. The needle protection system of the Arixtra pre-filled syringes have been designed with a. Please read this leaflet carefully before you start using Arixtra. This leaflet answers some common . package insert in each Arixtra carton. Mylan manufactures ARIXTRA®* (fondaparinux sodium) Injection, Solution ( Arixtra) in strengths of 25 mg05 mL 5 mgmL5 Category: Human Prescription Drug.

Author: Meshicage Kigagul
Country: Senegal
Language: English (Spanish)
Genre: Relationship
Published (Last): 27 August 2005
Pages: 18
PDF File Size: 3.47 Mb
ePub File Size: 4.84 Mb
ISBN: 379-1-83929-928-2
Downloads: 91059
Price: Free* [*Free Regsitration Required]
Uploader: Dosida

Antibodies to macromolecular platelet factor 4-heparin complexes in heparin-induced thrombocytopenia: Treatment and Prevention of Heparin Srixtra Thrombocytopenia: The incidence of HIT is greatest in unfractionated heparin use beyond 4 lackage at therapeutic doses.

However, they are also known to cause clinically relevant side effects, or adverse drug events, such as bleeding including hemorrhagic stroke, gastrointestinal bleeding, osteoporosis long-term usepriapism, and hyperkalemia from inhibition of aldosterone synthesis.

It is also worth noting that some patients with HIT have been shown to have platelet recovery with fondaparinux administration. Fondaparinux Arixtra is an anticoagulant that shares the same pentasaccharide sequence as UFH and LMWH for the binding to antithrombin, however it has no extra chain and thus, is not considered a heparin product.

  AMARILLI MIA BELLA PDF

While low-molecular weight heparins LMWH can also cause HIT, the incidence is much lower and appears to aeixtra related, in part, to the molecular weight. Research Triangle Park, NC.

Fondaparinux Sodium Injection — AuroMedics Pharma LLC

Please enter text to search. The reference to the chain is related to the part of the heparin molecule attached to the pentasaccharide sequence that is used in binding to antithrombin when exerting its antithrombotic effect. Treatment and prevention of heparin-induced thrombocytopenia: Explanation The use of anticoagulants, such as unfractionated heparin UFH and low-molecular weight heparin LMWH have significantly improved patient oriented outcomes for medical conditions related to thrombotic events.

The use of anticoagulants, such as unfractionated heparin UFH and low-molecular weight heparin LMWH have significantly improved patient oriented outcomes for medical conditions related to thrombotic events. Linkins LA et al. While the use of heparin based anticoagulants have improved patient oriented outcomes in patients with thrombosis related medical conditions, they paradoxically are also known to put some patients at risk for developing the life threatening thrombosis called heparin induced thrombocytopenia HIT.

  ESERCIZI MAL DI SCHIENA LOMBARE PDF

An evaluation of the molecular weights among the heparin related medications reveals that UFH’s molecular weight ranges from 3, to 30, daltons whereas, the LMWH range from 2, to 10, daltons. There are number of risk factors associated with increasing the chance for a patient to packags HIT, one of which is the type of anticoagulant used.

About Us Disclaimer Contact Us. For example, it is known that unfractionated heparin use, especially beyond 4 days of treatment, is known to have a greater risk for causing HIT when compared to LMWH dalteparin, enoxaparin, and tinzaparin. The arixttra of low molecular weight and standard heparin on calcium loss from fetal rat calvaria.

However, the longer the use especially if used at therapeutic doses the greater the incidence of HIT. As noted above, the length of the chain which influences the molecular weight contributes, in part, to heparin’s ability to bind to PF4 that triggers the immune mediated response seen in HIT.