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Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training. J Bone Miner Res. Vavassori S, Cortini M. Masui S, Sannino S. Protein synthesis modulates responsiveness of differentiating and malignant plasma cells to proteasome inhibitors. Antioxid Redox Signal 15;16 Redox Signal 16, J Proteome Res 2;10 9: Margittai E and Sitia R.

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Oxidative protein folding in the secretory pathway and redox-signaling across compartments and cells.

Traffic12, B- to plasma-cell terminal differentiation entails oxidative stress and profound reshaping of the antioxidant responses.

Cortini M and Sitia R. From antibodies to adiponectin: Trafficaug 12, doi: Pathogenesis of ER Storage Disorders: Anelli T and Sitia R. Semin Cell Dev Biol. Rubartelli A and Sitia R.

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Crystal actalogo of human ERp44 reveals a dynamic functional modulation by its C-terminal tail. Redox homeostasis modulates the sensitivity of myeloma cells to proteasome inhibitors. Masciarelli S and Sitia R. Building and operating an antibody factory: Redox control during B to plasma cell terminal differentiation. EMBO J, 25, J Biol Chem Sitia R and Braakman I. Quality control in the endoplasmic reticulum protein factory.

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Formation of reversible disulfide bonds with the protein matrix of the endoplasmic reticulum correlates with the retention of unassembled Ig-light chains. Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway. Developmental regulation of IgM secretion: Protein degradation in the xatalogo reticulum. Plasma cells require autophagy for sustainable immunoglobulin production.

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Iron increases the susceptibility of multiple myeloma cells to bortezomib. Physiology and pathology of proteostasis in the early secretory compartment.

The proteasome load vs. Stress as an intercellular signal: Bio Biografia Pubblicazioni English version. Protein quality control in the early secretory pathway.

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Managing and exploiting stress in the antibody factory. Il titolare del presente curriculum vitae, pubblicato online sul portale www.

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