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Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training. J Bone Miner Res. Vavassori S, Cortini M. Masui S, Sannino S. Protein synthesis modulates responsiveness of differentiating and malignant plasma cells to proteasome inhibitors. Antioxid Redox Signal 15;16 Redox Signal 16, J Proteome Res 2;10 9: Margittai E and Sitia R.


Oxidative protein folding in the secretory pathway and redox-signaling across compartments and cells.

Traffic12, B- to plasma-cell terminal differentiation entails oxidative stress and profound reshaping of the antioxidant responses.

Cortini M and Sitia R. From antibodies to adiponectin: Trafficaug 12, doi: Pathogenesis of ER Storage Disorders: Anelli T and Sitia R. Semin Cell Dev Biol. Rubartelli A and Sitia R.

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Crystal actalogo of human ERp44 reveals a dynamic functional modulation by its C-terminal tail. Redox homeostasis modulates the sensitivity of myeloma cells to proteasome inhibitors. Masciarelli S and Sitia R. Building and operating an antibody factory: Redox control during B to plasma cell terminal differentiation. EMBO J, 25, J Biol Chem Sitia R and Braakman I. Quality control in the endoplasmic reticulum protein factory.

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Formation of reversible disulfide bonds with the protein matrix of the endoplasmic reticulum correlates with the retention of unassembled Ig-light chains. Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway. Developmental regulation of IgM secretion: Protein degradation in the xatalogo reticulum. Plasma cells require autophagy for sustainable immunoglobulin production.


Iron increases the susceptibility of multiple myeloma cells to bortezomib. Physiology and pathology of proteostasis in the early secretory compartment.

The proteasome load vs. Stress as an intercellular signal: Bio Biografia Pubblicazioni English version. Protein quality control in the early secretory pathway.

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Managing and exploiting stress in the antibody factory. Il titolare del presente curriculum vitae, pubblicato online sul portale www.

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