The mediastinum is the most common extragonadal location. In adults, approximately % of mediastinal tumors are germ cell tumors;. 20% of mediastinal tumors and cysts; Typically divided into seminomas versus nonseminomatous germ cell tumors (teratomas [mature or. Mediastinal germ cell tumors are tumors that derive from germ cell rest remnants in the mediastinum. They most commonly occur in the gonad but occasionally.

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Germinoma with mediastinjm thymic cyst. Immunohistochemical staining for OCT4 has recently been validated as a powerful tool for detecting gonadal seminoma. Sarcoma Lymphoma Immature teratoma Melanoma. Pathology by regions G.

mediastinal germinoma

Fetus in fetu Dermoid cyst Struma ovarii Strumal carcinoid Trophoblastic neoplasm: These tumors are highly sensitive to radiation therapy and to combination chemotherapy. However, the cardiotoxicity of mediastinal radiation is substantial and the standard treatment of mediastinal seminomas is with chemotherapy using bleomycinetoposide and cisplatin for either three or four day treatment cycles depending on the location of any metastatic disease.

Patients with small tumors usually asymptomatic that appear resectable usually undergo thoracotomy and attempted complete resection followed by chemotherapy. The anterior mediastinum is the most common primary extragonadal site for germinal neoplasms in adults and is second to the sacrococcygeal region for pathologially comparable tumors in children.

Pathology Outlines – Germ cell tumors

The diagnosis of a mediastinal germ cell tumor should be considered in all young males with a mediastinal mass. Pure mediastinal seminomas are curable in the large majority of patients, even when metastatic at the time of diagnosis. Rare cases of adult onset acute megakaryoblastic leukemia are associated with malignant mediastinal germ cell tumor.


Malignant mediastinal germ cell tumors of various histologies were first described as a clinical entity approximately 50 years ago. These results and those of other analyses suggest that the two malignancies derive from a common founding clone of cells i.

Mediastinal germ cell tumor – Wikipedia

Initial treatment with four courses of bleomycin, etoposide, and cisplatin, followed by surgical resection of any residual disease, is considered standard therapy. Germ cell tumors[TI] mediastinum. Info – Admin Resources in pathology Technical section. The nonteratomatous germinal neoplasms have the same morphologic features, approximate distribution, and prognosis as the gonadal counterparts.

Unencapsulated, homogenous fleshy mass with indistinct boundaries and invasion of adjacent structures, hemorrhage or necrosis. Nasal cavity Esthesioneuroblastoma Nasopharynx Nasopharyngeal carcinoma Nasopharyngeal angiofibroma Larynx Laryngeal cancer Laryngeal papillomatosis.

Germ cell tumors of the mediastinum.

Mesothelioma Malignant solitary fibrous tumor. However, discrepancies between the genetic alterations and immunoprofiles of mediastinal and testicular seminomas have been reported, raising the question of whether techniques that are gfrminoma in the diagnosis of gonadal seminoma are applicable to its mediastinal counterpart.

In these cases, the mediastinal germ cell tumor develops before or concomitantly with but not after acute megakaryoblastic leukemia. Click here for information on linking to our website or using our content or images.


Please help improve it to make it understandable to germijomawithout removing the technical details. Usually males ages 20 – 49 years, similar to gonadal tumors Cancer ; Home About Us Advertise Amazon.

Also in this section mediastinal synovial sarcoma mediastinal low-grade extraskeletal osteosarcoma mediastinal pericytic medoastinum mediastinal leiomyosarcoma mediastinal leiomyoma mediastinal mesenchymal tumors mediastinal tumors mediastinal smooth muscle tumors mediastinal lymphomas mediastinal extramedullary hematopoietic tumor.

Germ cell tumor – mixed. Excised tumor with rib. Among the malignant germ cell tumors, males are affected far more commonly than females, but the male to female ratio is approximately equal among mature cystic teratomas.

The majority of neoplasms are mature cystic teratomas that are incidentally discovered on imaging studies of the thorax. Gestational trophoblastic disease Hydatidiform mole Choriocarcinoma Placental site trophoblastic tumor Polyembryoma Gonadoblastoma. From Wikipedia, the free encyclopedia.

Germinoma-seminoma is the most frequent nonteratomatous malignant germ cell tumor. Sign up for our Email Newsletters.

The treatment for mediastinal nonseminomatous germ cell tumors should follow guidelines for poor-prognosis testicular cancer. Thymic seminoma with marked cystic changes, superior mediastinum.