Request PDF on ResearchGate | On Jan 1, , S.D. Navaneethan and others published Inhibidores de la HMG CoA reductasa (estatinas) para pacientes en. Request PDF on ResearchGate | On Jan 1, , S.D. Navaneethan and others published Inhibidores de la HMG CoA reductasa (estatinas) para pacientes con. Los inhibidores de la enzima hepática HMG-CoA reductasa (estatinas), pueden indu- cir importantes reducciones en los niveles de colesterol plasmático y por.

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Therefore, statins metabolized through CYP3A4 simvastatin, lovastatin and atorvastatin are the ones with the highest number of clinically relevant interactions. Expert Opin Investig Drugs. Finally, a method was used to assess the clinical relevance of the interaction, based on the inhibidore of occurrence and the severity of the effect of the interaction.

HMG-CoA reductasa

Effects of rosuvastatin on platelet inhibition by clopidogrel in cardiovascular patients. Acute renal failure with the combined use of rosuvastatin and fenofibrate.

Rapid onset of muscle weakness rhabdomyolysis associated with the combined use of simvastatin and colchicine. Am J Health Syst Pharm. Effect of rosuvastatin on warfarin pharmacodynamics and pharmacokinetics. Inhibition of the organic anion-transporting polypeptide 1B1 by quercetin: Baycol withdrawn from market. Bases de datos de enzimas IntEnz: Interactions between simvastatin and troglitazone or pioglitazone in healthy subjects.


The effect of cholestyramine and activated charcoal on glipizide absorption. Jardine A, Holdaas H. Pharmacokinetic effects of fluvastatin in patients chronically receiving digoxin.

Accumulation of lovastatin, but not pravastatin, in the blood of cyclosporine-treated kidney graft patients after multiple doses. Rhabdomyolysis resulting from pharmacologic interaction between erlotinib and simvastatin. Fluvastatin in combination with cyclosporin in renal transplant recipients: Rhabdomyolysis caused by comedication with simvastatin and clarithromycin. The International Journal of Biochemistry 16 9: Effects of gemfibrozil and atorvastatin on the pharmacokinetics of repaglinide in relation to SLCO1B1 polymorphism.

Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: Effects of imatinib mesylate STI, Glivec on the pharmacokinetics of simvastatin, a cytochrome p 3A4 substrate, in patients with chronic myeloid leukaemia. Effect of fluvastatin for safely lowering atherogenic lipids in renal transplant patients receiving cyclosporine. FEBS Letters 1: Rhabdomyolysis induced by simvastatin-fluconazole combination.

Rifampin markedly decreases and gemfibrozil increases the plasma concentrations of atorvastatin and its metabolites.


HMG-CoA reductasa – Wikipedia, la enciclopedia libre

Fenofibrate and warfarin interaction. Effect of efavirenz on the pharmacokinetics of simvastatin, atorvastatin, and pravastatin: Am J Med Sci. Molden E, Andersson KS. Simvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazole.

No pharmacokinetic or pharmacodynamic interaction between atorvastatin and the oral direct thrombin inhibitor ximelagatran. Pharmacokinetic drug interaction between gemfibrozil and sitagliptin in healthy Indian male volunteers. Effect of itraconazole on the pharmacokinetics of atorvastatin.

Gemfibrozil concentrations are significantly decreased in the presence of lopinavirritonavir. Warfarin potentiation with bezafibrate. Reduced efficacy of rosuvastatin by St. Plasma concentrations of active simvastatin acid are increased by gemfibrozil.

Boguslawski W, Sokolowski W Paradoxical severe decrease in high-density lipoprotein cholesterol due to rosiglitazone-fenofibrate interaction.